Spheroid Array incorporated in Hydrogel as a Tissue-engineered Construct
نویسندگان
چکیده
منابع مشابه
Mechanical evaluation of a tissue-engineered zone of calcification in a bone-hydrogel osteochondral construct.
The objective of this study was to test the hypothesis that mechanical properties of artificial osteochondral constructs can be improved by a tissue-engineered zone of calcification (teZCC) at the bone-hydrogel interface. Experimental push-off tests were performed on osteochondral constructs with or without a teZCC. In parallel, a numerical model of the osteochondral defect treatment was develo...
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Current pharmaceutical compound screening systems rely on cell-based assays to identify therapeutic candidates and potential toxicities. However, cells grown on 2D substrata or in suspension do not exhibit the mechanical or physiological properties of cells in vivo. To address this limitation, the authors developed an in vitro, high-throughput, 3D hydrogel tissue construct (HTC)-based assay sys...
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Correction After publication of this work [1], the authors noted that there were some corrections that should be added to the work. These corrections are done in order to modify some parts that were unfortunately missed during the original publishing procedures. The authors would like to apologize for the inconvenience. Page 2 in the Methods section under “Mechanical loading studies and design ...
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BACKGROUND Current reconstructive techniques for continuity defects of the mandible include the use of free flaps, bone grafts, and alloplastic materials. New methods of regenerative medicine designed to restore tissues depend mainly on the so-called extrinsic neovascularization, where the neovascular bed originates from the periphery of the construct. This method is not applicable for large de...
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Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...
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ژورنال
عنوان ژورنال: Transactions of the Materials Research Society of Japan
سال: 2008
ISSN: 1382-3469,2188-1650
DOI: 10.14723/tmrsj.33.725